Dependence and addiction
Methamphetamine is highly addictive. Tolerance to methamphetamine develops quickly, meaning that higher doses are necessary to achieve the same effects or ‘high’. Many users compensate for this reduction in effect by taking increased doses, sometimes starting a cycle of drug use and withdrawal typical of methamphetamine dependence.
Psychological dependence occurs when users crave the drug so much that it becomes more important than other daily activities. People who become psychologically dependent find themselves unable to function without the drug.
Physical dependence occurs when the body becomes accustomed to operating on methamphetamine. Someone who stops using the drug may experience withdrawal symptoms, which include: fatigue, apathy, depression, irritability, craving and disorientation.
Overdose
High doses of methamphetamine intensify its effects and put increased strain on the user’s heart and brain. Overdose can result in seizure, stroke, heart failure, and increased body temperature. These effects can be fatal.